I think it would be interesting to see something DF-inspired at an MMO scale. I'd like to imagine what a larger team could do, with access to lots of parallel CPU power. DF does a lot of work abstracting things that are off-site, since a typical PC can't simulate the entire world in realtime. But if you had enough servers sharing the work, I expect you could do much more. Throw in a bunch of players all giving some direction to their own little autonomous civilisations, and I think it would be fascinating to watch.