As long as any old apk can be installed over ADB, f-droid just needs to release a desktop app, and I'm gtg. Yeah, it's a little inconvenient, and hopefully just a stopgap until Linux phones are viable, but still better than Apple.
It means users without a PC won't have this possibility. You will not be able to do squat if you are mobile-only. Maybe not a major change for us here but a dealbreaker for the majority.