Having been in academia, having felt the pressure, knowing reproduction is not sexy and takes time away from "actual experiments", knowing some theories or groups have cult-like status, knowing that not having papers means not getting a PhD, despite working hard, being smart, knowing that this is (experienced as) very unfair, etc... I'm very sure that 4 in 10.000 is the tip of the iceberg.

We need more reproduction. Or have some rule: Check all assumptions. Yes, it's a lot of work, but man will it save a lot of fake stuff from getting out there and causing a lot of useless work.