I saw trust being mentioned, but I don't really get it. Space is one of the most unnatural environments people can go to. Of course brains that had evolved for life on Earth can malfunction in such completely artificial spaces. Same for airplanes, or submarines, or modern warfare. There was a tense moment in Das Boot where the engineer suffered a mental breakdown while the sub was stuck on the ocean floor and the captain even felt the need to go get a pistol. It's not an issue of trust, it's basic psychology. Nobody wants to be "that guy" who puts everyone in danger, but I don't think there will ever be a reliable way to completely prevent such occurrences, nor do I think there is anyone to blame for them, and nor do I think having safeguards should be interpreted as a silent accusation towards those on board.
Yes, the resistance to something as simple as padlocking a hatch baffles me - it's like their integrity is being impugned by taking a simple and common sense precaution?