>This is alluded to in the article with polygenic risk scores, but those I suspect will face a similar crisis of replicability; although they predict outcomes, it's relatively weak when you get to behavior, and much weaker still upon replication.
Why would you say that? I think you implied you work in this field, so maybe you do know better than me. But from my perspective, you are incorrect. Not only a lot of SNP's are replicating, but we also have the definitive method to test causality, which is applying PGS intrafamily.
> The reason why I'm posting in response to your comment is that underlying all of this I think is a fundamental, often implied concern about BG research: that it is not oriented toward intervention, change, or improvement.
Ok, now I am definetely sure you don't work in the field. Wtf? Of course it is immensely valuable to know that cluster X of genes influences condition Y. Nowadays, drug discovery is a pretty messy process without any direction except trial and error. If we can previously know which genes are first implied in this condition, then we can reason what they are probably doing (using previous knowledge of them) and from there work in a possible solution.
Why would you say that? I think you implied you work in this field, so maybe you do know better than me. But from my perspective, you are incorrect. Not only a lot of SNP's are replicating, but we also have the definitive method to test causality, which is applying PGS intrafamily.
> The reason why I'm posting in response to your comment is that underlying all of this I think is a fundamental, often implied concern about BG research: that it is not oriented toward intervention, change, or improvement.
Ok, now I am definetely sure you don't work in the field. Wtf? Of course it is immensely valuable to know that cluster X of genes influences condition Y. Nowadays, drug discovery is a pretty messy process without any direction except trial and error. If we can previously know which genes are first implied in this condition, then we can reason what they are probably doing (using previous knowledge of them) and from there work in a possible solution.