I wonder, if mRNA tech offers the possibility of reintroducing lost of function for cells with mutations like p53 defects. E.g. maybe just do what p53 does, if it's present or not.
Much harder to identify the misbehaving cells, DNA deletions, than making all cells behave, I assume.
I think that is what CureVac is working on. RNA printers. I think even custom therapy can be produced but safety and efficacy is something they can't easily determine.