I tried to get it running a few weeks ago on Ubuntu, but gave up. It's pretty simple on Arch or Fedora currently, but Ubuntu seems to be lacking the necessary packages. Hopefully soon.
I just tried building it from source, and in the end I got everything right... On paper.
I got pulseaudio wrapped by pipewire-pulse, and applications launched and acted as if they produced audio (as opposed to being blocked), but I still couldn't get any sound.
Granted I have a complicated setup with a laptop with 2 HDMI outputs, 2 USB-soundcards, built-in headphone adapter and a built-in speaker.
Obviously that setup is going to take some configuration to get right, but with PulseAudio I could set it up pretty quickly with pavucontrol.
No such luck with PipeWire ... yet. I guess it will get there sooner or later :)