Per the FDA, Puerto Rico produced (pre-Maria) $40B of pharmaceuticals for the US alone.
40 of those products and devices were deemed critical as they're the only producer or there's no viable alternative [1].
The largest (in terms of unit count) production was Normal Saline with Baxter's P.R. factory supplying 50% of U.S. hospitals with small volume saline bags (<=250mL as opposed to the more common 1L) prior to Hurricane Maria which took out their production facility [2]. The hurricane is widely credited as the cause of our national saline shortage (though as [2] details, it exacerbated a shortage that already existed for several other reasons).
Per the FDA, Puerto Rico produced (pre-Maria) $40B of pharmaceuticals for the US alone. 40 of those products and devices were deemed critical as they're the only producer or there's no viable alternative [1].
The largest (in terms of unit count) production was Normal Saline with Baxter's P.R. factory supplying 50% of U.S. hospitals with small volume saline bags (<=250mL as opposed to the more common 1L) prior to Hurricane Maria which took out their production facility [2]. The hurricane is widely credited as the cause of our national saline shortage (though as [2] details, it exacerbated a shortage that already existed for several other reasons).
[1] (PDF warning): https://www.fda.gov/media/108975/download
[2]: https://www.nejm.org/doi/full/10.1056/NEJMp1800347