Given pg's recent boss essay, it would be interesting to hear more about this:

"We've all had experiences at big companies and also at start-ups and they both have their advantages and disadvantages. It is yet to be proven, but I believe it is actually possible to capture the best of both worlds: try to get the resources of a big company, but [also] the agility and ownership of a smaller company."

Paul Buchheit also gives an amazing interview in Founders at Work. I'm sure everyone here knows that book by heart.