You might expect 35mg psilocybin from 1/8 oz of mushrooms, which is a pretty mid to high, all day trip dose. So 25mg is strong but definitely not "ego death" strong.

Psilocybin content varies wildly in street mushrooms. I don't think a comparison between pharmaceutical grade psilocybin and illicit uncontrolled mushrooms is very useful.

I've witnessed lots of people losing their shit after eating an eighth.

It's still the same substance. The main difference is that with street mushrooms there's risk the dosage will be much higher, and that risk isn't there with a properly measured dose in a study.

Yep same substance but you misunderstand my point.

The risk here is that street mushrooms usually are going to be LESS potent than people think. What happens now, is that people pull the random statistic out of thin air saying "well 3.5g is about 35mg psilocybin so 25mg is good for the study." In reality, this dosage might end up being much higher than many of the positive anecdotes about "eating an eighth". And again, there's a million horror stories that use that same 3.5g weight.

That's why its silly to compare pharma-grade psilocybin with anecdotal evidence of street mushroom potency.

Seems like in certain tumor types it's better than FDG - still looking into it myself. Is FAPI available in the US already?

Thanks for sharing. You got FDG PET ("older") as well as FAPI? Are you in the US? Curious if FAPI is already in wide use.... does FDG not work that well for NET ?

I am in the US and FDG PET does not work for NET. The "older" scan was Pet radiolabeled with indium-111. Comparison is here: http://prntscr.com/o02jsg Left is the newer scan, which uses Gallium 68. The primary tumor is uppermost right side, liver metastasis is left side, and small lower lighted up areas are lymph nodes. All will be removed soon. Lit up area below is the radiotracer in my bladder before urinating. :-)

Strange to see images from my specialty here on HN, but no. On the right hand side you have a classic planar OctreoScan (and from posterior view at that). What you have on the left side is a 68Ga-DOTA-(TOC/NOC/TATE) scan, not the new 68Ga-FAPI scan which I believe is only available in Heidelberg, Germany for now. While 68Ga-DOTA-(TOC/NOC/TATE) are probably not as good as 68Ga-FAPI (we don't know that yet, pending research) it is markedly better than OctreoScan, especially for small primary lesions, as is often the case in NETs. Source: I am an MD specialized in nuclear medicine.

Wow! Do you have DICOM files for that! Good thing they found all that! Good luck with all the surgery, you'll get better soon!

Yes I have all the Dicom files and put all the images on a password protected server so I can share with prospective surgeons. This really helped me find the best possible surgeon. THANKS!

Minor side note: I did that too but found that institutions were locked down and could not access my public server, and they wouldn’t accept a usb drive with the same data. They were only set up to receive FAT dvds - and I spent many, many hours duping DVD’s for doctors in their waiting rooms.

The USB thing might be a security policy in action. The DVD (and that's weird, because I think I've never seen DVDs, but lots of CDRs) is probably a historical thing related to the DICOM Supplement 19 General Purpose CD-R Image Interchange Profile standard.

Sorry, this is not true. 68Ga-labelled DOTATOC, DOTANOC, and DOTATATE are used diagnosis and therapy of NETs for more than 10 years. They are widely available in Europe and in some major US centers. If the new 68Ga-FAPI will be better remains to be seen, I suppose the Heidelberg group will publish some research soon.

I just took him at his word that it was FAPI & was asking if it is available in the US - also I favor PET as a modality b/c it's quantitative. No judgement on a particular tracer.

You are correct it's only in the last several years this Gallium 68 scan has been available in the US, but was available in Europe long before - like many cancer treatments.

Yes it was an Octreotide scan.

You're right but that's an additional layer of abstraction - check out the article / paper, they built a 6-bit "computer" using DNA and DNA superstructures only.

You're saying suicidal ideation is "the natural state"?

I think he's saying non-existence is the natural state and the decision to live and expend energy gathering resources just to survive needs to be justified, rather than be expected to justify your wish to stop existing.

I think the counter to that is the idea that human life is inherently valuable and doesn't need to be justified.

You shouldn't make this argument without supporting it in any way. Why does it have inherent value? Life doesn't have inherent value to us as a collective society. Look at livestock. We've had countless pointless wars where people die horrible deaths. Abortion is legal in many parts of the world. Humans have made tons of negative impacts on our planet like tossing literal tons of plastic in the ocean.

I agree that human life is valuable, but you have to support your claim in some way. If you can't find a way to support it, then maybe the claim is wrong.

Not yet. I think they're well (more?) aware of potential consumer backlash.

The analysis of your sequence is key. While there are some open source resources (hard for non-experts to use), the big consumer testing companies far and away have better analytical tools.

When anyone can sequence their DNA at home I expect this to change.