>Wouldn't car parts be a much more accurate analogy, though?
Yes. The FCC actually sent out reminders to phone companies two days ago reminding them that use of aftermarket parts cannot void a warranty. This also applies to things like "warranty void if seal removed" stickers etc.
It does a little bit. The FCC has teeth when it comes to maintaining their regulations. There's little else you can do to bring suits to your door faster than to operate an unlicensed transmitter. The FTC is not so potent, as indicated by the behavior of all these cell phone manufacturers for the past decade.
I don't understand why the geniuses at Apple haven't seen the obvious flaws in our American/European/Asian/etc wall plugs and sockets and created Apple branded proprietary wall plugs and sockets that are totally incompatible with all current American/European/Asian/etc. plugs and sockets. Apple products would all use the proprietary plugs, while 'obsolete' devices with standard plugs would require a $40-100 Apple adapter. The Apple home isn't truly going to be an Apple Home until you can't plug a non-Apple device into a wall socket without forking over money to Apple for an unnecessary adapter.
The 30-pin connector lasted from the third-gen iPod (2003) through the iPhone 5 (2012), or around nine years. Lightning has remained the connector of choice since then for the past six years.
MagSafe debuted in 2006, was improved to MagSafe 2 in 2012, and is being phased out for USB-C (which is terrible, but I digress) in 2018.
One change in fifteen years for their handheld product lineup and two changes in twelve years for their laptop lineup seems pretty reasonable.
Asian outlets are amazingly versatile: they happily take both European and US plugs. It's a real pleasure not having to bring converter plugs with you. I am still wondering why airports all over the world have not adopted them.
Most power adapters for electronic devices will take any AC input from 100-240v and transform accordingly to the device (which cares more about DC), but definitely check before plugging it in. The Americas and Japan are 100-127v, and the rest of the world is 220-240v with a few discrepancies here and there. They also range from 50hz-60hz AC, so some devices that rely on the frequency for time may slow or speed up depending on what region they were made and where they are used.
No, but they are making it very difficult for anyone to use, for example, non-Apple-branded cloud storage. And they are making it nearly impossible for anyone to use non-Apple-approved apps.
> they are making it very difficult for anyone to use, for example, non-Apple-branded cloud storage
Which is why they added support for arbitrary file providers to integrate with iOS 11's Files app, and why they announced that iWork will support collaborating through Box last month?
I still can’t use whatever SMS app that I want to. I still can’t replace Safari as the browser that opens links from apps. I can’t replace contacts or the phone dialer and I can’t open contact address links in anything but Apple Maps.
Heck, they don’t even let me organize my home screen the way that I want to.
That wasn't my point. My point was that all those requests are feature requests, as opposed to lifting some artificial restrictions. Because iOS is not open source, they would need to be coded by Apple, so it's a perfectly valid business decision on their sise not to invest in them.
I don't know. Those all seem like valid complaints to me. The os is separate from the applications and everything he listed has its own industry.
Microsoft was reamed over installing IE as the default browser on their OS, so how is not letting you change safari as the default on iOS any different?
Coulda said the same thing with Microsoft, go buy a Mac. Monoply power isn't a binary stat, it's a sliding scale and eventually these companies get enough power to start affecting other industries
I know. That's my point. People are complaining about decisions made by the company as if they're civil rights violations.
"I can't change the default SMS app on my phone!" This has always been the case with the iPhone since the beginning. Until Apple says that this is now a new part of the OS, pretending like that was some kind of bait and switch or deceptive business practice is completely silly.
> People are complaining about decisions made by the company as if they're civil rights violations.
No they aren't - not here at least. Scanning this thread, it looks like they're just complaining.
> pretending like that was some kind of bait and switch or deceptive business practice is completely silly.
Who did that? Can you point out a specific comment? I certainly didn't and I don't see any other comments that did. I simply pointed out how Apple makes their product difficult to use by being so stingy with the level of access that they allow me to have.
Anyway, there is an anti-trust lawsuit against Apple right now. Since their iPhone does have somewhere around 50% marketshare in the USA I think there's a chance for it to succeed and I hope it does.
>Anyway, there is an anti-trust lawsuit against Apple right now.
And what are the damages claimed against them? Even if they have 50% marketshare, they still have competition with a larger marketshare both domestic and worldwide. There's nothing that can be brought against them because they're not doing anything illegal or immoral.
Heck even apple approved charging cables sometimes give me the "this accessory might not work correctly on this device". Gives me pause, but it goes away once I retry...
I was actually thinking that plain old bolts, also available at the hardware store, imagine if Ford could ban all 8mm bolt import and sales just because they had one in one of their cars
You'd be surprised. Heart disease, for example, is one of the deadliest age-related diseases, but it's by no means exclusive to the wealthy. See for example the World Health Organization's statistics[0]; they report that three quarters of deaths from cardiovascular disease occur in low-income and middle-income countries.
The Buck Institute [0], featured in this article, is a pretty outstanding organization -- they're unique in being a sizable research center devoted to researching aging. I'm excited to see their idea of age-related diseases as biological maintenance problems gaining some traction.
I'm not entirely sure where the interviewer was going with this statement, though.
> There’s a lot of Silicon-Valley buzz about longevity and many startups working to develop immortality pills.
I've yet to hear of a startup working on an "immortality pill."
There are certainly startups / small companies working on rejuvenation therapies, however, ways to repair the forms of damage that cause aging rather than merely slowing down that damage a little as is the case for calorie restriction mimetic drug development.
See for example these entities working on means to selectively remove senescent cells, with Unity Biotechnolgy being the one connected to Buck Institute researchers:
The presence of senescent cells have been shown to directly cause failure of regeneration, fibrosis, fibrotic lung diseases, loss of tissue elasticity, blood vessel calcification, faster progression of atherosclerosic lesions, arthritis, chronic inflammation, immune system dysfunction, and retinal degeneration, just to name a few items from papers published in the past two years. More links are being established in research papers with each passing year. The removal of these cells has been shown in mouse studies to quickly reverse the age-related progression of many of these items.
See also Mount Tam Biotechnologies, a spin-off from the Buck Institute focusing on mTOR modulators, shown to extend lifespan in mice. Their initial application addresses Lupus, an autoimmune disease.
Unity will be starting human trials this year, so far as we know.
Oisin will follow later this year or in 2018, if they keep to the standard way in which things work in biotech companies following an A round.
I have no idea what SIWA will be doing; they have been around on life support for a while, and now resurrected by the newfound money coming into the field. I'd imagine that their next step would be some form of trial, though it is unclear as to where exactly they are in their animal study schedule.
There are people self-experimenting with senolytic drug candidates now, though not in any way that will provide useful data. If you draw the line at candidates for which there is in vivo evidence in mammals, you're left with just the chemotherapeutics and foxo4-dri. (A pity that fisetin has no in vivo evidence yet...). The chemotherapeutics are worth skipping over, since they are ugly chemicals and really only a starting point for the development of analogs without the horrible side-effects, and foxo4-dri hasn't been tested in any formal way in humans yet.
At the pace at which new drug candidates are emerging and being tested, a couple of years from now would be a good time to be self-experimenting.
Elysiums key ingredient is nicotinamide riboside, a recently discovered pre cursor to NAD+ which has shown incredible results when it comes to slowing down aging. You can buy NR supplements pretty easily and I can't recommend it enough if you're into this stuff.
The next thing is NMN (nicotinamide mononucleotide) but currently it's way too expensive to buy for individuals. There are some Chinese labs synthesizing it for cheap but unless you have access to a lab I wouldn't trust it's what it says it is. Though it's very likely that we will see accessible supplements in the next 3 years.
In fact, NMN was so promising in rats/mice that Keio university in Tokyo just started human trials.
NR (the stuff you can buy already) gets converted to NMN in your body though.
I for now am taking NR (not elysium) daily until some big study tells me not to or until I find a reliable NMN source. What has been discovered so far convinced me to give it a try just for the offchance that it's really doing what people say it does.
We live in exciting times and I am very much looking forward to see what the next years has to offer.
I second this one! It's the only resource I've needed and still use for flexbox. I've got most use cases committed to memory by now, but every now and then I need to visually see what I'm trying to do and quickly reference its code.
Surely the projections cited in this article aren't accurate.
> Already operating in 191 countries and 34,000 cities, analysts at financial services company Cowen & Co predict that, by 2020, Airbnb hosts will be taking 500 million bookings a night, rising to a staggering one billion by 2025.
If the population of the world is about 8.2 billion in 2025, which is the UN's expectation [0], that'd mean one Airbnb booking a night per eight humans on Earth. Perhaps they mean yearly, not nightly?
Extrapolated from their numbers, in 2045 it will be an unbelievable 16 billion, 2 bookings a night per human. All that vacationing will lead to vacation fornication and generate the increase in population needed to sustain the growth. What a keen business model.
Much of this article (and all of the images) was taken from a WWDC 2015 talk [0]. If you're interested in typography, that video is definitely worth a watch.
A few years back, Bill Gates said that he'd be working in biology if he were still a teenager [0]. There's a lot of exciting work happening in the field, and if anyone finds this sort of thing particularly inspiring, I'd encourage them to read up on bioinformatics -- there's plenty of programming work to be done in the biosciences.
It's a pretty awesome time to be a biologist. Things are happening so quickly and profoundly. In sequencing alone, imagine having 30 years of Moore's law progress in 5 [1]; that just happened and we are still catching up to the consequences. Then there are GWAS, CRISPR, organoids, ESCs/iPSCs, superres microscopy, immunotherapy, etc. Also it is true that computational approaches will play a big role [2].
I'm not looking to get hired, but I am looking to do statistical analysis/Manhattan plot for endometriosis variant identification using a patient group, and develop a therapy using CRISPR. Would you be able to recommend anyone I could connect with?
I don't really see biology attracting the same kind of intellect that programming does. There is an enormous, and constantly growing, amount of minutiae that must be simply remembered by rote. It seems much closer to law than to computer science.
If, instead, I were choosing exclusively based on the importance of the work for humanity, I would still go for energy research before biology. That is what civilization's survival hinges on.
